abstract：:Most Thai orchid farmers heavily used pesticide mixtures, and were shown to have various hematologic/immunologic alterations. The present study investigated the effect of exposure of male Wistar rats to a mixture of three pesticides (chlorpyrifos, cypermethrin and captan) that are most often used by the farmers. Three...

journal_title：Environmental toxicology and pharmacology

authors： Aroonvilairat S,Tangjarukij C,Sornprachum T,Chaisuriya P,Siwadune T,Ratanabanangkoon K

更新日期：2018-04-01 00:00:00

abstract：:A simple analogue of well known natural antioxidant glutathione (GSH) called S-allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GG...

journal_title：Environmental toxicology and pharmacology

authors： Thayumanavan P,Loganathan C,Iruthayaraj A,Poomani K,Nallaiyan S

更新日期：2018-03-01 00:00:00

abstract：:The in situ evaluation of the genotoxic impact of the Karaj River was performed using the comet and micronucleus (MN) assays in erythrocytes, liver, gill and kidney of indigenous brown trout, Salmo trutta fario from three different stations, including Varangerud, Asara and Purkan. The results showed that DNA damage si...

journal_title：Environmental toxicology and pharmacology

authors： Hariri M,Mirvaghefi A,Farahmand H,Taghavi L,Shahabinia AR

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, o...

journal_title：Environmental toxicology and pharmacology

authors： Khazdair MR,Rajabi O,Balali-Mood M,Beheshti F,Boskabady MH

更新日期：2018-03-01 00:00:00

abstract：:The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...

journal_title：Environmental toxicology and pharmacology

authors： Park HJ,Choi WS,Lee WY,Choi Y,Park C,Kim JH,Hong KH,Song H

更新日期：2018-03-01 00:00:00

abstract：:The aim of this work was to evaluate the Ascidian Embryo Teratogenicity assay (AET) as new alternative invertebrate model to test the developmental effects of the co-exposure to ethanol and fluconazole. Ciona intestinalis embryos were exposed to the azolic fungicide fluconazole, (FLUCO, 7.8-250μM), to ethanol (Eth, 0....

journal_title：Environmental toxicology and pharmacology

authors： Battistoni M,Mercurio S,Ficetola GF,Metruccio FC,Menegola E,Pennati R

更新日期：2018-01-01 00:00:00

abstract：:Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it ...

journal_title：Environmental toxicology and pharmacology

authors： Chhay P,Murphy-Marion M,Samson Y,Girard D

更新日期：2018-01-01 00:00:00

abstract：:Roundup Original® is an herbicide widely used in Mato Grosso's agriculture and it may contamine water bodies, being an unforeseen xenobiotic to aquatic organisms, particularly fish. This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally ...

journal_title：Environmental toxicology and pharmacology

authors： de Moura FR,da Silva Lima RR,da Cunha APS,da Costa Marisco P,Aguiar DH,Sugui MM,Sinhorin AP,Sinhorin VDG

更新日期：2017-12-01 00:00:00

abstract：:Butyl benzyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity. However, BBP leaches off of plastic and environment presence has been detected in soil, groundwater and sediment potentially effecting organisms in the environment. Given the widespread uses of B...

journal_title：Environmental toxicology and pharmacology

authors： Roy NM,Zambrzycka E,Santangelo J

更新日期：2017-12-01 00:00:00

abstract：:Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquat...

journal_title：Environmental toxicology and pharmacology

authors： Robson L,Barnhoorn IEJ,Wagenaar GM

更新日期：2017-12-01 00:00:00

abstract：:Air pollution is a topic discussed all over the world and the search for alternatives to reduce it is of great interest to many researchers. The use of alternative energy sources and biofuels seems to be the environmentally safer solution. In this work, the deleterious effects on the respiratory system of mice exposed...

journal_title：Environmental toxicology and pharmacology

authors： Josino JB,Serra DS,Gomes MDM,Araújo RS,de Oliveira MLM,Cavalcante FSÁ

更新日期：2017-12-01 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt-100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs ma...

journal_title：Environmental toxicology and pharmacology

authors： Chen S,Liang H,Yang H,Zhou K,Xu L,Liu J,Lai B,Song L,Luo H,Peng J,Liu Z,Xiao Y,Chen W,Tang H

更新日期：2017-10-01 00:00:00

abstract：:Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the...

journal_title：Environmental toxicology and pharmacology

authors： Cocci P,Mozzicafreddo M,Angeletti M,Mosconi G,Palermo FA

更新日期：2017-10-01 00:00:00

abstract：:To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed t...

journal_title：Environmental toxicology and pharmacology

authors： Zhang S,Chen H,Wang A,Liu Y,Hou H,Hu Q

更新日期：2017-10-01 00:00:00

abstract：:Earthworms are the key soil organisms, contribute to many positive ecological services that could be degraded by pesticides and other soil pollutants such as heavy metals. Chemicals usually occur as mixtures in the environmental systems which can lead synergistic effects. The assessment and characterization of soil po...

journal_title：Environmental toxicology and pharmacology

authors： Uwizeyimana H,Wang M,Chen W,Khan K

更新日期：2017-10-01 00:00:00

abstract：:Bisphenol A (BPA) is shown to be the endocrine disruptor that induces reproductive dysfunction in male animals. In this study, we aim to probe the effects of BPA exposure on induction of autophagy in goat Sertoli Cells (gSCs), as well as the relationship between autophagy and apoptosis. Results indicated that exposure...

journal_title：Environmental toxicology and pharmacology

authors： Zhang Y,Han L,Yang H,Pang J,Li P,Zhang G,Li F,Wang F

更新日期：2017-10-01 00:00:00

abstract：:Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35day...

journal_title：Environmental toxicology and pharmacology

authors： Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

更新日期：2017-09-01 00:00:00

abstract：:A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are de...

journal_title：Environmental toxicology and pharmacology

authors： da Silva Simões M,Bracht L,Parizotto AV,Comar JF,Peralta RM,Bracht A

更新日期：2017-09-01 00:00:00

abstract：:Impact of smoking on the levels of apolipoprotein B (APOB) was evaluated by analyzing data from National Health and Nutrition Examination Survey for the years 2007-2012 for US adolescents aged 12-19 years and adults aged >=20 years. When adjustments were made for the effects of age, gender, race/ethnicity, body mass i...

journal_title：Environmental toxicology and pharmacology

authors： Jain RB

更新日期：2017-07-01 00:00:00

abstract：:The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...

journal_title：Environmental toxicology and pharmacology

authors： Lingabathula H,Yellu N

更新日期：2017-06-01 00:00:00

abstract：:The ecological risks posed by two β-diketone antibiotics (DKAs, enrofloxacin, ENR and ciprofloxacin, CPX), characterized by their long persistence in aqueous environments and known deleterious effect on model organisms such as zebrafish were analysed using Rhinella arenarum larvae. Sublethal tests were conducted using...

journal_title：Environmental toxicology and pharmacology

authors： Peltzer PM,Lajmanovich RC,Attademo AM,Junges CM,Teglia CM,Martinuzzi C,Curi L,Culzoni MJ,Goicoechea HC

更新日期：2017-04-01 00:00:00

abstract：:Environmental Epigenomics is a developing field to study the epigenetic effect on human health from exposure to environmental factors. Endocrine disrupting chemicals have been detected primarily in pharmaceutical drugs, personal care products, food additives, and food containers. Exposure to endocrine-disrupting chemi...

journal_title：Environmental toxicology and pharmacology

authors： Tapia-Orozco N,Santiago-Toledo G,Barrón V,Espinosa-García AM,García-García JA,García-Arrazola R

更新日期：2017-04-01 00:00:00

abstract：:The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20-160mg/L) on 7 and 14days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, r...

journal_title：Environmental toxicology and pharmacology

authors： Zhang C,Shao Y,Zhu L,Wang J,Wang J,Guo Y

更新日期：2017-04-01 00:00:00

abstract：:Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of N...

journal_title：Environmental toxicology and pharmacology

authors： Zhang J,Zhou X,Wu W,Wang J,Xie H,Wu Z

更新日期：2017-04-01 00:00:00

abstract：:In this study, Al2O3, CuO and TiO2 nanoparticles (NPs) were administered to mature female rats (Rattus norvegicus var. albinos) via oral gavage (0, 0.5, 5, 50mg/kg b.w./day) for 14days to investigate their effects on 14 serum biomarkers and 4 antioxidant enzyme (catalase, superoxide dismutase, glutathione peroxidase, ...

journal_title：Environmental toxicology and pharmacology

authors： Canli EG,Atli G,Canli M

更新日期：2017-03-01 00:00:00

abstract：:Nanoparticles have been implicated in the development of pleural effusions in exposed factory workers while in experimental animal studies it has been shown that they induce inflammation, fibrosis and carcinogenesis in the pleura. The scope of this study was to investigate the direct effects of silver nanoparticles ex...

journal_title：Environmental toxicology and pharmacology

authors： Arsenopoulou ZV,Taitzoglou IA,Molyvdas PA,Gourgoulianis KI,Hatzoglou C,Zarogiannis SG

更新日期：2017-03-01 00:00:00

abstract：:To investigate the toxic effects of dietary overload lithium on the adipogenesis in adipose tissue of chicken and the role of hypothalamic neuropeptide Y (NPY) in this process, one-day-old male chicks were fed with the basal diet added with 0 (control) or 100mg lithium/kg diet from lithium chloride (overload lithium) ...

journal_title：Environmental toxicology and pharmacology

authors： Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

更新日期：2017-01-01 00:00:00

abstract：:Previous research has demonstrated that lipopolysaccharide (LPS) can induce sepsis and lead to myocardial dysfunction. Naringin has various biological activities in LPS-induced sepsis. In this study, our aim was to investigate the effects of Naringin on LPS-induced cardiac injury and clarify its potential mechanism. W...

journal_title：Environmental toxicology and pharmacology

authors： Xianchu L,Lan PZ,Qiufang L,Yi L,Xiangcheng R,Wenqi H,Yang D

更新日期：2016-12-01 00:00:00

abstract：:To elucidate the potential thyroid disrupting effects of refuse leachate on females, female goldfish (Carassius auratus) were exposed to 0.5% diluted leachates from each step of a leachate treatment process (i.e. raw leachate before treatment, after membrane bioreactor treatment, and the final treated leachate) for 21...

journal_title：Environmental toxicology and pharmacology

authors： Gong Y,Tian H,Zhang X,Dong Y,Wang W,Ru S

更新日期：2016-12-01 00:00:00

abstract：:Coniferaldehyde (CA) exerts anti-inflammatory properties by inducing heme oxygenase-1 (HO-1). To define the regulation mechanism by which CA induces a cytoprotective function and HO-1 expression, the up-stream regulations involved in the activation of nuclear transcription factor-erythroid 2-related factor (Nrf)-2/HO-...

journal_title：Environmental toxicology and pharmacology

authors： Kim KM,Heo DR,Kim YA,Lee J,Kim NS,Bang OS

更新日期：2016-12-01 00:00:00

abstract：:Hexavalent chromium-mediated oxidative stress causes severe organ damage. The present study was designed to investigate the possible thyroprotective effect and underlying mechanisms of gallic acid using rat model of potassium dichromate-induced thyroid dysfunction. Forty adult male albino rats were divided into 4 grou...

journal_title：Environmental toxicology and pharmacology

authors： Mohamed HM,Abd El-Twab SM

更新日期：2016-12-01 00:00:00

abstract：:Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions...

journal_title：Environmental toxicology and pharmacology

authors： Gramec Skledar D,Peterlin Mašič L

更新日期：2016-10-01 00:00:00

abstract：:The cytochrome P450 enzyme 2E1 (CYP2E1) presents in both microsome and mitochondrion, which influences the metabolism of many xenobiotics. The mice active liver homogenate was prepared for the medicinal incubation and mitochondrion was extracted for chemical screening targeting CYP2E1 enzyme. Representative CYP2E1 ind...

journal_title：Environmental toxicology and pharmacology

authors： Wang M,Zhou Z,Wang J,Zhang X

更新日期：2016-10-01 00:00:00

abstract：:Juvenile rockfish, Sebastes schlegelii (mean length 16.4±1.9cm, and mean weight 71.6±6.4g) were exposed for 20days with the different levels of waterborne arsenic concentration (0, 50, 100, 200 and 400μg/L). The plasma cortisol of S. schlegelii was significantly increased by the waterborne arsenit exposure. In the imm...

journal_title：Environmental toxicology and pharmacology

authors： Kim JH,Kang JC

更新日期：2016-10-01 00:00:00

abstract：:Acyclovir (ACV) exposure is a common cause of acute kidney injury (AKI). The toxicity mechanism of ACV has always been a matter of debate. The present study investigated into the time-effect relationship and dose-effect relationship of ACV-induced nephrotoxicity in rats using metabonomics. Twenty-four rats were random...

journal_title：Environmental toxicology and pharmacology

authors： Xing W,Gu L,Zhang X,Xu J,Lu H

更新日期：2016-09-01 00:00:00

abstract：:In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) and on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (1...

journal_title：Environmental toxicology and pharmacology

authors： Fu G,Zhou C,Wang Y,Fang W,Zhou J,Zhao S,Ma L

更新日期：2016-09-01 00:00:00

abstract：:Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled "safe" by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Give...

journal_title：Environmental toxicology and pharmacology

authors： Roy NM,Ochs J,Zambrzycka E,Anderson A

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:The study aims to verify whether alterations in the level of neurotransmitters have occurred in prenatally stressed rats (animal model of schizophrenia), and whether aripiprazole (ARI) and olanzapine (OLA) modify this level. METHODS:The effects of ARI (1.5mg/kg) and OLA (0.5mg/kg) were studied by means of m...

journal_title：Environmental toxicology and pharmacology

authors： Ratajczak P,Kus K,Gołembiowska K,Noworyta-Sokołowska K,Woźniak A,Zaprutko T,Nowakowska E

更新日期：2016-09-01 00:00:00

abstract：:Serious bacterial pathogens have recently become a major cause of massive mortality in swimming crabs (Portunus trituberculatus). In this study, the antibacterial activity against Vibrio and the pharmacokinetics (PK) of sulfamethoxazole (SMZ)-trimethoprim (TMP) in crabs were estimated to explore the pharmacokinetics/p...

journal_title：Environmental toxicology and pharmacology

authors： Fu G,Peng J,Wang Y,Zhao S,Fang W,Hu K,Shen J,Yao J

更新日期：2016-09-01 00:00:00

abstract：:Cigarette smoke (CS) is a well-known risk factor for carcinogenesis and has been found to be related to the occurrence and development of colon cancer. In this study, the effect of formaldehyde (FA), benzene (Bz), and isoprene (IP), which are included in main components of CS, on cell viability and apoptosis of SW620 ...

journal_title：Environmental toxicology and pharmacology

authors： Lee HM,Kim CW,Hwang KA,Choi DW,Choi KC

更新日期：2016-07-01 00:00:00